Epidemiologic Research
The Center continues to expand established success in research on the epidemiology of aging and longevity. A major focus of research has been and will continue to be on maintenance of function and prevention of disability. The CAPH conducts: Observational Studies, Clinical Trials, Community base participatory research, Global Health, Dissemination and Implementation Research and Translational Research.
Active Studies
1. Alzheimer’s Disease and Alzheimer’s Related Dementias in Prediabetes and Type 2 Diabetes: The Diabetes Prevention Program Outcomes Study AD/ADRD Project
U19 AG078558
2022-2027
PI: Elsa Strotmeyer, PhD, MPH
The DPPOS AD/ADRD project will address the overarching question: What are the determinants and the nature of cognitive impairment among persons with pre-diabetes (PreD) and type 2 diabetes (T2D), who are a high-risk group for cognitive impairment and represent a large fraction of the United States (US) population? This U19 proposal addresses the National Alzheimer’s Project Act goal to “prevent, halt, or reverse AD” in the high-risk group of persons with pre-diabetes and type 2 diabetes, who represent over half of the population aged 60 years and older in the US.
2. Reducing Inflammation for Greater Health Trial (RIGHT)
WoodNext Foundation
2022-2026
PI: Anne B. Newman, MD, MPH
The RIGHT study will examine the effects of clazakizumab (5 mg per month), a medication that blocks inflammation, on energy level and walking ability of older adults over a six-month period. Clazakizumab has been used for the treatment of other conditions with inflammation, such as rheumatoid arthritis. It is currently approved only for experimental use by the FDA (Food and Drug Administration).
Pitt+Me ~ Reducing Inflammation for Greater Health Trial: The RIGHT Study
3. Study of Muscle, Mobility and Aging (SOMMA)
R01 AG059416
2018-2029
MPIs: Anne B. Newman, MD, MPH, Steve CummingsSFCC, Stephen Kritchevsky, PhD Wake Forest, Russ Hepple, UFl, Bret Goodpaster, Adventist Health
SOMMA, a multicenter research study funded by the National Institutes of Health, began in 2018. Two clinical centers in the United States, Wake Forest University School of Medicine and University of Pittsburgh, recruited 879 men and women from Pittsburgh, PA and Forsyth County, NC, for the baseline visit (2019-2022). Enrollees were age ≥70 years, able to walk ≥0.6 m/s (4 meters), able to complete 400m walk, free of life-threatening disease, and had no contraindications to magnetic resonance or tissue collection. The baseline visits included collection of biospecimens (muscle and adipose tissue, blood, urine); a variety of questionnaires; physical and cognitive assessments; whole-body imaging (magnetic resonance); accelerometry; and cardiopulmonary exercise testing (CPET). Annual in-person visits have occurred with the third annual visit repeating many of the same measurements as baseline, including CPET. Since the baseline visit, participants have been contacted by phone every six months regarding physical function, health status, living arrangement, medical history, and ascertainment of hospitalizations, cancer diagnoses, falls, fractures, death, and cardiovascular events. An extensive bank of data, images (MR scans, x-rays, HRpQCT scans), and specimens have been archived as part of SOMMA and it’s ancillaries. A new round of exams and new recruitment will occur starting in 2025.
Study of Muscle, Mobility and Aging (SOMMA) | Center for Aging and Population Health
SOMMA Ancillary Studies (4-8)
4. Neural and Energetic Drivers of Performance and Perceived Fatigability in Older Adults
NIA R01 AG075025
2022-2026
PI Caterina Rosano, MD, MPH
We examine the contribution of dopaminergic neurotransmission, dopaminergic networks’ activity, and brain energy metabolism, to physical performance fatigability in older adults. We propose these neuro-energetic markers, individually and in combination, may explain fatigability beyond what is predicted by skeletal muscle energetics and cardiopulmonary function.
5. The relationship between protein intake, gut microbiome, inflammaging and loss of mobility in older adults
NIA K01AG071855
2022-2026
PI: Samaneh Farsijani, PhD
We are in dire need to determine if higher protein intake, above the current recommendation (0.8/kg/d), can produce long-lasting beneficial effects to prevent age-related loss of muscle mass and function in older adults. This proposal determines the long-term effects of higher protein intake on prevention of age-related mobility disability; and identifies if dietary proteins enhance mobility function by improving the gut bacterial composition and reducing inflammation in the body. Findings from this K01 can drive age-specific dietary recommendations, replacing the current one-size-fits-all approach, to enhance mobility function in older adults by improving gut health and inflammation; and the acquired skills will help the Principal Investigator to integrate omics (gut microbiome) and non-omics (dietary intake) data towards a long-term career goal to develop “Precision Nutrition” strategies and age-specific dietary advice to promote healthy aging.
6. The relationship between blood-based bioenergetics and muscle function, mobility, and aging
R01AG072734
2022-2026
PI: Sruti Shiva, Anthony Molina
Older adults experience declining mobility, which leads to diminished quality of life, high health care costs, and thus constitutes a major health care problem. It is unclear what factors lead to mobility decline, but energy production by the mitochondrion is thought to play a role. This longitudinal study utilizes new methodology to measure systemic mitochondrial function in blood cells of older people over time, to understand the role of mitochondrial function in age-associated physical function decline.
7. Investigating the role of adipose tissue in mobility and aging (SOMMA-AT)
NIA R01AG066474
2020-2025
MPIs: Sparks Lauren M, Kershaw, Erin E
The SOMMA project is a large-scale trial designed to determine key biological properties of skeletal muscle that are related to incident major mobility disability, declines in mobility and declines in fitness in older adults (> 70yr) over the course of three years, while also collecting adipose tissue (AT) and blood. The experiments proposed in this ancillary study will examine the influence of AT structure and function on AT-secreted proteins that are related with mobility disability and can directly impact skeletal muscle function. The proposed work will also quantify the AT-secreted proteins in circulation that are found to directly affect skeletal muscle function, as well as contribute all excess biospecimens to the parent SOMMA project biorepository for future use.
8. Bone Microarchitecture and Bone Strength Relationships to Muscle Quantity, Quality and Function in Older Adults
NIA R01 AR076752
2019 – 2024
MPIs: Jane A. Cauley, DrPH; Elsa S. Strotmeyer, PhD, MPH
We extended SOMMA to include important skeletal measures of bone strength using high-resolution peripheral quantitative computed tomography (HRpQCT). To our knowledge, no studies have linked ATP-max and quadriceps contractile volume to volumetric BMD, microarchitecture and strength (failure load as assessed by finite element analysis). We will examine these characteristics globally and separately in the trabecular and cortical compartments and in a weight bearing (tibia) and non-weight bearing (radius) bone site. This SOMMA ancillary study is the first to study novel properties of muscle biology, volume, and functional power and their relationships to bone strength in a well- characterized population of older men and women.
9. Long Life Family Study (LLFS)
NIA U01AG023744
2004-2025
MPIs: Joseph M. Zmuda, PhD, Anne B. Newman, MD, MPH
Exceptionally long lived and healthy older adults and their families are examined to determine the combined genetic and environmental factors contributing to longevity in families at 4 field centers in the US and Europe. Families from the United States and Denmark will help us learn why some people live until a very old age and why some families maintain their health far longer than the average family.
10. Early Age-Related Hearing Loss Investigation (EARHLI): A Randomized Controlled Trial to Assess the Mechanisms Linking Early Age-Related Hearing Loss and Alzheimer’s Disease and Related Dementias
NIA R01 AG075083
2022 – 2027
PI: Nancy W. Glynn, PhD, FGSA, FACSM
This is a subcontract for a project responsive to PAR-18-877 to “develop and implement early stage (Phase I or II) clinical trials of promising…non-pharmacologic interventions” including “in individuals with…presymptomatic…stages of disease.” Because age-related hearing loss is highly prevalent, uncommonly treated, and recognized as a major risk factor for Alzheimer’s disease and related dementias, this project is of high public health significance and potential high impact.
11. Predictors of Altered CNS Structure, Function, and Connectomics in the Elderly using a Health Disparities Framework
NIA R01 AG072641
2022 – 2027
PI: Nancy W. Glynn, PhD, FGSA, FACSM
As we learn more about how the brain controls thinking and behavior, we are learning that the connections between different parts of the brain may be at least as important as what happens in the individual brain regions. This is a subaccount with an overall goal to understand how changes in the physical connections between brain regions affect how these brain regions are able to communicate with each other and how this affects overall brain function, thinking, and behavior. We will study how racial differences in the development of cognitive impairments in older Americans are driven by pervasive structural and institutionalized inequities that shape risk and disadvantage.
12. The Study of Muscle, Aging and Physical Performance in African Caribbeans
NIA R01 AG074956
2022 –2026
PI: Iva Miljkovic, MD, PhD
African Caribbeans have a high burden of diabetes, muscle fat infiltration and muscle weakness, which may lead to higher levels of age-related physical limitations and disability; however, there is currently no comprehensive information from individuals in this geographic region on muscle and physical performance. Therefore, this study seeks to directly measure skeletal muscle mass, and comprehensively phenotype physical performance in a large, established cohort of African Caribbean men and women living on the island of Tobago. This information can be used in future efforts to better prevent age-related declines in muscle and physical performance – an enormous public health issue – which will greatly enhance the quality of life of older adults in this region.
13. Osteoporotic Fractures in Men (MrOS)
NIAMS U01 AR045654
2009-2026
PI: Jane A. Cauley, DrPH
Six clinical center observational cohort study focused on identifying potentially modifiable risk factors for osteoporotic fractures, neuromuscular function and falls in older men. MrOS began in 2000. Six clinical centers in the United States, located in Birmingham, AL; Minneapolis, MN; Palo Alto, CA; the Monongahela Valley near Pittsburgh, PA; Portland, OR; and San Diego, CA recruited 5,994 men at the baseline visit (2000 -2002). The baseline examination included the assessment of risk factors for fractures and other conditions, including neuromuscular, visual and cognitive function tests; bone mineral density (BMD); x-rays of the spine; QCT scans of the hip and spine and the collection of biospecimens.
14. Aspirin in Reducing Events in the Elderly (ASPREE)
NIA U01AG029824
2009-2024
PI: Anne B. Newman, MD, MPH
This is a randomized double-blind placebo-controlled trial of aspirin in primary prevention in healthy elderly people aged 65/70 years and over, which determined that low dose aspirin did not extend the duration of disability- free life in an aging population. The potential benefits of this drug (particularly the prevention of heart disease, stroke and vascular dementia) did not outweigh the risks of severe bleeding in this age group. ASPREE is the largest primary prevention aspirin study ever undertaken in healthy older people. Follow-up has been continued after the primary results were reported.
15.Cardiovascular Health Study (CHS)
NHLBI N01HC85082
1988-2028
PI: Anne B. Newman, MD, MPH
CHS is a four-field center, observational cohort study initiated by the National Heart, Lung and Blood Institute (NHLBI) in 1987 to determine the risk factors for development and progression of cardiovascular disease (CVD) in older adults, with an emphasis on subclinical measures of atherosclerosis. The study recruited 5,888 adults aged 65 or older at entry in four U.S. communities and conducted extensive annual clinical exams between 1989-1999 along with semi-annual phone calls, events adjudication, and subsequent data analyses and publications. Additional data were collected by studies ancillary to CHS. Analysis of this data is still ongoing.
CHS Ancillary Studies (16-19)
16. Exceptional Aging: 12 Year Trajectories to Function
CHS All Stars, NIA R01AG023629
2004-2016
PI: Anne B. Newman, MD, MPH
This study of functional aging, or disability-free survival, examines the long-term survivors of the Cardiovascular Health Study to determine the likelihood of maintaining function, identify the trajectories that distinguish those destined to do well, and define the importance, independence and interactions of physiologic predictors of function.
17. Predictors of Alzheimer’s Disease in Mild Cognitive Impairment
NIA R01AG020098
2002-2011
PI: Oscar Lopez, MD
The goals of this study are to examine the natural history of AD in the Pittsburgh CHS Memory I study, from a normal cognitive state to dementia onset, with especial emphasis on the transitional phase Mild Cognitive Impairment, including repeat MRI and cognitive testing.
18. The Sleep Heart Health Study
NHLBI U01HL077813
1994-2007
PI: Anne B. Newman, MD, MPH
This is a longitudinal multi-center multi-cohort study including the CHS cohort that began in 1994 to determine the cardiovascular consequences of sleep disordered breathing including mortality and morbidity follow-up of the cohort.
19. Does Kidney Function Determine Aging Success
NIA R01AG027002
2005-2022
PI: Linda F. Fried, MD, MPH
This grant is an ancillary study to the Cardiovascular Health Study to evaluate whether kidney function predicts successful aging and changes in risk factors associated with successful aging.
20. Women’s Health Initiative (WHI)
NHLBI N01WH32112
1993-2026
PI: Jane A. Cauley, DrPH
The Women’s Health Initiative (WHI) was a landmark, long-term national health study that has focused on strategies for preventing heart disease, breast and colorectal cancer, and osteoporotic fractures in postmenopausal women. These chronic diseases are the major causes of death, disability, and frailty in older women of all races and socioeconomic backgrounds.
WHI Ancillary Studies (21-25)
21. Hormone Therapy, Estrogen Metabolism and Risk in WHI
NHLBI N01WH74320
2007-2009
PI: Lewis H. Kuller MD, DrPH
This contract was awarded under a program to maximize the scientific yield from the biologic resource and associated participant exposure and outcome data in the Women’s Health Initiative (WHI), with the objective to elucidate whether differences in estrogen metabolism in untreated women and women on estrogen therapy determine risk of hip fracture and breast cancer.
22. Biochemical Antecedents of Fracture in Minority Women
NHLBI N01WH74318
2007-2011
PI: Jane A. Cauley, DrPH
This study is designed to maximize the scientific yield from the biologic resource and associated participant exposure and outcome data in the Women’s Health Initiative (WHI), through improved understanding of the biochemical factors that predict the risk of fracture in minority women and to test whether these factors are independent of other risk factors such as body weight, smoking, and physical activity.
23. Anemia and Its Relationship with Sarcopenia and Mortality
U AZ Y481844
2007-2010
PI: Jane A. Cauley, DrPH
This is a subcontract for participation in an ancillary study to the Women’s Health Initiative focusing on anemia. Measurements of body composition are examined in order to investigate the association of anemia with skeletal muscle loss.
24. Estradiol, Cytokines and Bone Turnover: Effect on Fracture
NIAMS R01AR052105
2005-2007
PI: Jane A. Cauley, DrPH
This is a case-cohort study of sex steroid hormones, Vitamin D, cytokines and bone turnover in relationship to hip fracture in two cohorts (SOF and WHI).
25. Women’s Health Initiative – The Memory Study (WHIMS)
N01WH44221
2003-2011
PI: Lewis H. Kuller MD, DrPH
This is a subcontract for participation in an ancillary study to the Women’s Health Initiative focusing on dementia, mild cognitive impairment, and global cognitive function in women who participated in the estrogen + progesterone or estrogen-alone hormone treatment trials. The purpose is to determine if taking hormones prevents dementia or slows the decline of cognitive function.
Past Studies with Available Data
26. Enabling Reduction of low-Grade Inflammation in Seniors (ENRGISE)
NIA U01 AG050499
2015-2021
PI: Anne B. Newman, MD, MPH
This randomized clinical trial tested the ability of anti-inflammatory interventions for preventing major mobility disability by improving or preserving walking ability. Specifically, in this trial we tested the efficacy vs. placebo of the angiotensin receptor blocker losartan and omega-3 polyunsaturated fatty acids in the form of fish oil, alone and in combination.
pubmed.ncbi.nlm.nih.gov/30202946
27. Mobility and Independent Living in the Elderly Study (MILES India)
Dean’s Global Health Fund
2011-2019
MPIs: Anne B. Newman, MD, MPH, Jane A. Cauley, DrPH
We established a longitudinal cohort study in India to define the prevalence, incidence and risk factors for disability and age-related disease and in the population of older adults (50+) in the Andhra Pradesh region near Hyderabad. The increase in the older population is most rapid in developing countries and in the oldest old. There is a need for more detailed data on the prevalence and causes of disability in these countries and also an opportunity to better understand the causes and consequences of disease by examining cross-cultural differences. The Indian population is not well described, but evidence suggests that the current demographic transition provides a unique opportunity to better understand the potential for future disability.
28. Imaging Biomarkers of Accelerated Brain Aging in Type-1 Diabetes
NIDDK 5R01DK089028
2010-2016
PI: Caterina Rosano, MD, MPH
Brain changes are common in persons with Type 1 Diabetes (T1D) and they are strikingly similar to abnormalities observed in older adults. We characterized the nature of accelerated brain aging in T1D (cerebral perfusion, neural activation and micro-structure level) and identify their determinants.
29. Comparative Effectiveness of Community-Based Falls Prevention in Pennsylvania
CDC NCCDPHP 1U48DP002657
2010-2013
PI: Steven Albert, PhD, MSPH
This study is a randomized controlled trial involving the Pennsylvania Department of Aging’s Healthy Steps and Healthy Steps in Motion programs to examine their effect on risk of falls over 12 months.
30. The Testosterone Trial
NIA 1U01AG030644
2009-2015
PI: Jane A. Cauley, DrPH
The Testosterone trial or TTrial is a randomized trial in hypogonadal men aged 65 and older designed to test whether testosterone treatment results in improved physical and sexual function and vitality in older men, with secondary endpoints of cognition and coronary calcification. It was conducted in about 800 men in 12 cities across the US. Many of the outcomes, including the Bone Trial are a rich source of data for our investigators.
31. Study of Energy and Aging (SEA)
NIA RC2AG036594
2009-2011
PI: Anne B. Newman, MD, MPH
We hypothesized that decreased skeletal muscle mitochondrial capacity to generate energy plays a pivotal role in age-associated decline in mobility. To test this hypothesis, an interdisciplinary team will lead assessments and analyses of components of the ‘energetics system’ from muscle oxygen delivery to the energy efficiency of walking. These assessments include phosphorous spectroscopy for in-vivo muscle ATP generation, muscle biopsies with measurements of mitochondrial content and function, blood flow to the legs with exercise, and energy utilization during walking.
In the study, 38 men and women ages 70-89 years with a wide range of mobility, examined in 2011. To lay the foundations for future longitudinal studies of energy production, disability, and fatigue, SEA tested several novel measurements of mitochondrial function, in-vivo ATP production, and other standard myocellular features for correlations with mobility, exertional fatigue during walking, and leg muscle strength and mass and establish their intra-subject reproducibility. Findings from SEA ultimately led to the funding of the SOMMA study.
32. Epidemiologic Study of Bone Marrow Fat and Osteoporosis
NIAMS 1RC1AR058162
2009-2012
PI: Jane A. Cauley, DrPH
This proposed study provided the research community with novel understanding toward the etiology of osteoporosis, especially in older men. It opened a new opportunity for prevention and/or treatment of osteoporosis and osteoporotic fractures among at-risk populations.
33. Osteoarthritis Initiative (OAI)
NIAMS P60AR054731
2007-2012
PI: Jane A. Cauley, DrPH
The Osteoarthritis Initiative (OAI) was a multi-center, longitudinal, prospective observational study of knee osteoarthritis to facilitate the scientific evaluation of biomarkers for osteoarthritis as potential surrogate endpoints for disease onset and progression.
www.niams.nih.gov/grants-funding/funded-research/osteoarthritis-initiative
34. Global v. Focal Neuroimaging Markers of Dementia Risk
NIA R03AG025076
2006-2008
PI: Caterina Rosano, MD, MPH
The goal of this project was to identify and quantify specific neuroimaging markers of Alzheimer Disease (AD) using an automated brain MRI reading technique, the automated labeling pathway (ALP).
35. In Vivo PiB PET Amyloid Imaging: Normals, MCI & Dementia
NIA 5P01AG025204
2005-2010
PI: William Klunk, MD, PhD, Co-I: Oscar Lopez, MD and Lewis H. Kuller MD, DrPH
The overall objective of this proposal was to define amyloid deposition in early phases of AD and aid in the characterization of PIB as a surrogate marker of amyloid deposition by examining PIB retention and other metabolic and structural makers. Two of the three studies that are part of this program project grant will continue follow up of participants in the GEM Study who underwent PiB imaging in the final year of the GEM trial.
36. Physical Exercise to Prevent Disability (LIFE)
NIA 2U01AG02237
2003-2018
PI: Anne B. Newman, MD, MPH
LIFE was a Phase 3, single-masked multicenter randomized controlled trial to compare a moderate-intensity physical activity program to a successful aging health education program in sedentary older persons who are at risk of disability. The trial provided definitive evidence regarding whether physical activity is effective and practical for preventing major mobility disability.
Based upon promising results from a pilot study among 424 sedentary older adults who were randomized to a physical activity intervention or a successful aging health education intervention, a Phase 3 multi-center randomized controlled trial was conducted to compare a moderate-intensity physical activity program to a successful aging health education program in 1,600 sedentary older adults who are followed for an average of 2.7 years. The physical activity program showed a 17% reduction in mobility disability, setting the benchmark for future studies testing other approaches.
37. Safety and Efficacy of Zoledronic Acid in Osteoporosis
Novartis CZOL446H2301
2002-2013
PI: Jane A. Cauley, DrPH
This was a multicenter, double-blind, randomized, placebo- controlled study to evaluate the safety and efficacy of zoledronic acid in the treatment of osteoporosis in postmenopausal women taking calcium and vitamin D.
38. The Effects of Weight Loss on Sleep Apnea in Patients with Type 2 Diabetes (Sleep AHEAD)
NHLBI R01HL70301
2001-2009
PI: Anne B. Newman, MD, MPH
As an ancillary study to the Look AHEAD Study, this research was designed to determine the efficacy of a weight loss program in reducing sleep disordered breathing (SDB) in obese type 2 diabetics with obstructive sleep apnea (OSA), identify sources of variability in SDB associated with weight loss, and examine the role of SDB in mediating changes in blood pressure associated with weight loss.
39. Health Aging and Body Composition (Health ABC)
NIA N01AG62101
1996-2016
PI: Anne B. Newman, MD, MPH
The Health, Aging and Body Composition Study is an interdisciplinary study focused on risk factors for the decline of function in healthier older persons, particularly change in body composition with age. The study was designed to address differences in onset of functional limitation, disability and longevity between older men and women as well as between Blacks and Whites.
Health ABC Ancillary Studies (40-49)
40. Peripheral nerve decline: an underappreciated cause of injurious falls
NIA R01AG028050
2011-2015
PI: Elsa S. Strotmeyer, PhD, MPH
This renewal ancillary study to the Health Aging Body Composition Study (Health ABC) is designed to define for the first time the clinical outcomes of poor peripheral nerve function including fall injuries requiring medical care, fractures, medical utilization, expenditures, and mortality in older adults.
41. End of Life in the Very Old
NINR R01NR012459
2011-2015
PIs: Steven Albert, PhD, MSPH, June Lunney PhD
The goal of the was to provide information on a broad- based sample of elders aged 85+ in order to improve care at the end of life in advanced age. We continued follow- up of participants in the Health ABC over an additional 3 years.
42. Resilience to Mobility Impairment: Neural Correlates and Protective Factors
NIA R01AG037451
2011-2015
PI: Caterina Rosano, MD, MPH
This is a longitudinal neuroepidemiological study to identify the brain characteristics and risk factors of older adults who have maintained good mobility in the face of substantial structural brain abnormalities.
43. Racial Disparities in Older Adults: Impact of Medicare Part D
NIA R01AG034056
2009-2010
PI: Joseph Hanlon, PharmD, MS
The long-term objective of this study is to reduce racial disparities in health outcomes by examining the impact of this policy intervention of increasing prescription drug coverage among the elderly.
44. Impact of Medicare Part D on Racial Disparities in Diabetes Treatment and Outcome
AHRQ R01HS017695
2009-2011
PI: Julie Donohue, PhD
The long-term objective of this study is to reduce racial/ethnic disparities in health by examining the impact of changes in insurance coverage among the elderly.
45. Vitamin D, falls, fractures, and function in community- dwelling older adults
NIA R01AG029364/ WFUHS11200/Kritchevsky
2007-2009
PI: Jane A. Cauley, DrPH
The goal of the project was to advance our understanding of the role of Vitamin D in function and bone health by measuring circulating 25(OH) D and parathyroid hormone levels in archived samples from the Health ABC study in a cohort of black and white, well-functioning, community-dwelling men and women aged 70-79.
46. Peripheral Nerve Function Decline in an Aged Cohort
NIA R01AG028050
2007-2010
PI: Elsa S. Strotmeyer, PhD, MPH
This study will determine the declines in peripheral sensory and motor nerve function over seven years in older white and black adults in the Health, Aging and Body Composition (Health ABC) Study cohort, the risk factors for these declines, and if the rate of decline is prospectively related to rate of recurrent falls and a decline in self-reported walking ability over two years.
47. Brain Anatomical Correlates of Mobility Control in the Oldest Old
NINDS R01AG029232
2007-2015
PI: Caterina Rosano, MD, MPH
This longitudinal epidemiological research project will investigate the association of focal brain magnetic resonance imaging (MRI) abnormalities with changes over time in age-related mobility impairment that are not associated with specific neurological diseases, such as strokes or Parkinson’s disease.
48. Novel Brain Neuroimaging Markers of Age-Related Mobility Impairment
Healthy Brain Project
NIA K23AG028966
2006-2008
PI: Caterina Rosano, MD, MPH
The study aims are to identify the earliest structural white matter (WM) and gray matter (GM) changes associated with unexplained age-related mobility impairment, to examine the spatial and temporal relationship of WM and GM subclinical abnormalities in mobility-related areas, and to identify the possible causes and risk factors of such brain abnormalities.
49. Study of Osteoporotic Fractures (SOF)
NIA R01AG027576
1986-2016
PI: Jane A. Cauley, DrPH
Conducted at four clinical centers, this was a twenty-year observation cohort of originally 9,704 women focused on osteoporotic fractures and successful aging.
University of Pittsburgh
Center for Aging and Population Health
130 N Bellefield Ave
Pittsburgh, PA 15213
